– Bonnie Crater, founder and vice-chair of the Board of Directors, Bay Area Lyme Foundation

“I was driving down a road that I’ve driven 1,000 times and suddenly I had no idea where I was or where I was going. So, I pull over to the side of the road to get myself oriented, and then 5-10 minutes later, I remembered and drove to my destination.”

Several friends affected by Lyme have told me of this same experience. It’s caused by the brain fog symptom of Lyme disease, which is often called “mild cognitive impairment” by physicians. I first learned about brain fog when my friend Laure and I founded the Bay Area Lyme Foundation. She explains it like this:

“My nature is to be prompt, attentive and on top of things. It’s important to me to remember people and conversations, and follow up later. Brain fog makes me feel like my brain is muffled with cotton, and it turns me into a “flake” which is very frustrating and hard for me to accept. There are times my brain has been so confused and my spatial awareness is so poor that I’ve actually walked right into a wall. Often, when I am experiencing brain fog, I have to read paragraphs numerous times, and can’t comprehend the content or remember the beginning of the paragraph by the time I’ve gotten to the end.”

As you can imagine, experiencing brain fog—and the cognitive dysfunction involving memory problems, lack of mental clarity, and poor concentration that comes along with it—is very scary for Lyme patients.

So, what is brain fog? It is defined as a temporary state of diminished mental capacity marked by inability to concentrate or to think or reason clearly. For Lyme patients, brain fog seems to manifest by decreasing your ability to think, causing you to feel confused or disorganized and making it difficult to focus or put thoughts into words. So, why do Lyme patients suffer from it? To unpack this a bit, let’s look at some research. Nearly 20 years ago in 2000, Dr. Diego Cadavid and other researchers published a study in Nature where they explored the dissemination of the Lyme bacteria Borrelia burgdorferi (Bb) in non-human primates. They found the bacteria in several organs including the skeletal muscle, heart (aorta), and bladder. They also found the bacteria in the primate brains (pictured below).

Localization of B. burgdorferi: A, spinal cord leptomeninges; B, anterior nerve root; C, dorsal root ganglia; D, epineurium

For some Lyme patients, the brain fog they experience can, in severe cases, resemble some phases of Alzheimer’s disease. In a curious related finding, Dr. Alan MacDonald discovered Bb in a large percentage of Alzheimer’s brains—7 of 10 Alzheimer’s brains had signs of a Bb infection in his 2007 pilot study. If Bb and brain fog are connected, that raises an interesting question: How might infection with Bb in the brain be causing brain fog?

In 2012 I met Jay Rajadas at Stanford University. His father-in-law sadly had Alzheimer’s disease, and Dr. Rajadas became very interested in studying amyloid plaques found in the brain of Alzheimer’s patients. He also wanted to investigate a possible connection to Borrelia infection. To gain more insight, Dr. Rajadas initiated a study and Bay Area Lyme Foundation and the L.K. Whittier Foundation funded this initial research. By 2015, Dr. Rajadas had started collaborating with additional researchers. Together, they conducted laboratory and mouse studies to understand the impact Bb may have on neurons in the brain. They hypothesized that the lipopeptides, fatty compounds that are sloughed off by the Bb bacteria, may interfere in the communication between neurons. They conducted PET scans on mice and tested the effect of the presence of a synthetic lipopeptide on the communication of neurons. What they found is that, in the presence of the lipopeptide, the density of the communication sites between neurons were significantly lower and there was a disruption in the synaptic signaling. This result suggests that some neural pathways might get disrupted. Could this disrupted signaling be causing the brain fog?.

What does this mean for Lyme patients? This week, results of years of hard work were published in the Journal of Neuroscience that provide clues that answer this question.  For the first time, researchers have demonstrated that lipopeptides associated with Bb cause dysfunction in the brain of mice. It also gives us more to consider.

If this research is confirmed by others, we now have a new hypothesis to test: Do lipopeptides disrupt neural pathways? And, if we can keep Lyme patients free of lipopeptides in the brain, will they stop having brain fog symptoms? While the lipopeptide effect is exciting new information, more research is needed to confirm these findings and find solutions for Lyme patients. The work today offers another clue about how Lyme disease causes neurological symptoms and another piece of information we can use to solve the Lyme disease problem.

Our hope is that one day Lyme disease will be easy to diagnose and simple to cure.

19 Comments on “New Study Provides Insight Related to Lyme Brain Fog

  1. I’m asking Patrick Jordan about Hulda Clark Zapper. Did you ever experience Lyme healing with this method? Also, did you hear about the Andersen family and their lyme success story? Obtained with diet only?

  2. I was misdiagnosed with early-onset Alzheimer’s back in 2007 using a CAT scan designed to detect brain cancer (glucose uptake). My symptoms were similar to the article, except for the emergence of 50-year-old memories as is commonly found in Alzheimer’s patents. My neurologist would not accept my suggestion of neuroborreliosis and forced me to retire with a disability. My symptoms continued to improve and, in 2017, I was retested with a new amyloid PET scan and found amyloid-free. Neuropsychology testing showed a 95% recovery. I don’t know if ten years of Razadyne and Namenda helped.

  3. Congratulations to Jay Rajadas and his team for their interesting research studies and results. Wish him and his team further success in their ongoing investigation.

  4. Lyme brain fog could most easily be explained by circulating pro-inflammatory cytokines, which is likely why it clears when people take stimulants. Stimulants decrease pro-inflammatory cytokines and also help decrease pain due to Lyme disease.

    1. More importantly: WHAT pro-inflammatory cytokines? The immune signalling chemicals are not the enemy. As Alan MacDonald showed, it is the filarial worms burrowing into the CNS that bring the Borellia in like a taxi cab that are the problem, so without the inflammation there will be no immune response and without an immune response then there will be no addressing the invaders, therefore all that was accomplished is TOLERANCE which will let the invaders create havoc, but the victim will just not feel it. What is the Kill Shot for the worms and spirochetes?

    2. “Lyme brain fog could most easily be explained by circulating pro-inflammatory cytokines, which is likely why it clears when people take stimulants.” Thank you for mentioning this!

      I’ve personally experienced a release from Lyme brain fog while taking phentermine for weight loss. After a month I described to my doctor that I felt like I was in the movie Limitless. The difference was incredible. Is there research to back stimulants being beneficial for brain fog? It’d be a lot easier to justify long term use for a diagnosis other than weight loss.

  5. I discovered my bullseye third week of July 2013. There’s a lot to the story. My brain is working just like what you described in this article. I think I have a solution to get the brain’s connections working properly. Please don’t laugh or think I’m nuts. I chewed a very small pinch of magic mushrooms. For three days all the racing, fog and forgetfulness disappeared. There were no hallucinations by the way. Calmness, yes. If this is what normal feels like, I want more. Please contact if you would like hear more.

    1. Nothing to laugh at, but cause for great concern. It is well documented that Lyme & company facilitate viral re-activation or infection. So far, we have identified that opioids and anything that work on those neuroreceptors allow cell permisivity to Herpes virus, at the very least; this implicates alcohol as well. THC allows viral penetration. Next we were to look into nicotinic and muscarinic receptors but there is just so much a few humans can do in a lifetime. Clearing symptoms seems to be the focus in the guru sphere of dealing with Lyme but mostly the interventions only create tolerance for the invader, never getting rid of the root cause. I don’t deny the perception of removal of symptoms, I just question the mechanism of action.

    2. I am interested in hearing more. I’m having a real difficult time with brain function/ rational thinking right now.

  6. I’m a 68-year-old grandpa that’s had seven back surgeries, shoulder repair, and left new knee. Been fighting Lyme disease for nine years. Muscles hurt, joints hurt, brain fogs. The list goes on and on. My entire family has this disease and a buddy of mine and his family. We know where we got it. I pray everyday for my grandchildren and children for some type of relief. I’m getting tired of fighting and surgeries are no longer an option because of my brain and lungs. You reach a point of your life where you say enough is enough. Basically our families are bankrupt. We live day-to-day, paycheck-to-paycheck.

    1. Bill, My son has Lyme disease, but is not sure how he got it. You say that you and your family know where you got it and I would like to pass that information on to my son. Thanks so much, Harry Lee

    2. Bill, both of my children and I have it as well. It’s amazing in the Lyme groups how often you see whole families with Lyme. It’s not talked about enough. Like you, desperate for relief but even more so for my children.

  7. I have brain fog…I am a Diabetic..I have had tick bites and now have lots of sores with the center missing. I stay tired. I do my house work if I feel like it. I am 71. I am a Registered Nurse. I have had no luck finding someone to help me. I now have one patient. Me: I itch most of the time. Take a lot of Benadryl. I have wondered if I have Morgellons Disease or Lyme disease. I live in a small town in Kentucky. The doctors don’t have a clue. I do a lot of research on this. I need help. I just asked for an EGD. It was done 3 days ago. I can’t eat. Have heartburn extremely bad and bloating..Not psychotic, this is real. I need help.

    1. Carla, If you suspect Lyme or a tick-borne disease, we would strongly encourage you to see a specialist familiar with these illnesses. The International Lyme and Associated Diseases Society (ILADS) maintains a database of clinicians and can point you in the direction of an informed care provider in your area. Continue to document your symptoms including description; date, time, and duration of incidence; and any changes (improvement or deepening) of symptoms. You may even want to take photos. The more information you can share with your doctor, the better equipped they will be to diagnose. Best wishes.

    2. I am studying the work of a fellow who links Morgellons to the Bartonella co-infection of what is falsely called Lyme. Since tickspit must contain more than just spirochetes, it can never just be spirochetes but polymicrobial infection. MacDonald demonstrated filarial worms as the delivery vehicle for the Borrelia. Those burrow through the body like swiss cheese, so itching would be a given with just the nematodes, let alone all other causes. Why antibiotics are pushed like used car sales but anti-parasite herbs are never mentioned is a crime in itself. Another thing we are trying to harmonize is the totality of spirochetal presence: Leptospirosis is as easily gotten as a kiss from a dog or horse that has been rooting in the dirt. Helicobacter Pylori is yet another pandemic that is covered up worldwide. Hulda Clark said that reflux was from bacterial overgrowth on the hiatus. If the sphincter cannot close due to muscle weakness then the acid will reflux. Acid was never the enemy, in fact, it is supposed to protect us from the invaders. I have been experimenting with cayenne and tabasco peppers with mixed results because unfermented peppers come with lectins and alkaloids that bring their own problems. Ancient herbal tradition was to make the GI tract inhospitable for the invaders. It seems reasonable, but they might pack up and move to different tissue, so we have to have a comprehensive program to kill them, not just relocate them. Antibiotics create Cell Wall Deficient forms so using allopathic drugs makes the problem a thousand times worse than not treating it. These conditions are never ‘in your head’ except for the fact that neuroborreliosis is… in your head…

  8. This makes me wonder also about memory and the effect Lyme has on it. Both short and long term memory seem to be damaged. In people who have been successfully treated that had these symptoms, are the memories regained or are they gone for good? If short term memories are needed to be translated into long-term ones, will there be no long-term memories from that period of time? Isn’t this part of cognition?

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