Chase Beisel PhDLaure Woods Emerging Leader Award Recipient, Chase Beisel, PhD
Assistant Professor, Department of Chemical & Biomolecular Engineering, NC State University

Dr. Beisel is an Assistant Professor in the Department of Chemical & Biomolecular Engineering at North Carolina State University.  His lab pursues research on using the Type 1 CRISPR-Cas system to cleave and degrade the bacterial genome. The approach has so far been tested successfully in E. coli, Salmonella enterica and Streptococcus thermophilus. He has received funding for his work in anti-microbials from the National Science Foundation and the Gates Foundation. Dr. Beisel received his BS in Chemical Engineering from Iowa State University and a PhD in Chemical Engineering with a minor in Biology from the California Institute of Technology. His project, described below, was selected for the 2016 Laure Woods Emerging Leader Award.

Project Overview
Dr. Beisel’s ELA award will utilize CRISPR-Cas genome targeting in Borrelia burgdorferi. If successful, the work will provide a proof of principle demonstration that targeting the Borrelia genome with CRISPR is lethal. The project will also assess the anti-microbial efficacy of CRISPR against B. burgdorferi and will elucidate the Borrelia genome’s potential mechanisms of escape from CRISPR attack.