Dr. Sabeti is a computational geneticist with expertise developing algorithms to detect genetic signatures of adaptation in humans and the microbial organisms that infect humans. Her lab’s key research areas include: (1) Developing analytical methods to detect and investigate evolution in the genomes of humans and other species, (2) examining host and viral genetic factors driving disease susceptibility to West African disease, (3) investigating microbial genomes to develop intervention strategies, and (4) determining the microbial cause of undiagnosed acute febrile illness. Dr. Sabeti—along with others—has hypothesized that an infection of genetically diverse Borrelia burgdorferi, also known as co-infections, may be the cause of the high variability in Lyme disease symptoms and to the clinical outcomes for patients. Leveraging their experience with Ebola, Dr. Sabeti and her colleagues will study hundreds of blood samples from Lyme patients and determine the Borrelia strains and species that are causing the infections. Her group will use the latest in gene sequencing techniques to provide the foundation for a next generation Lyme disease therapy. Dr. Sabeti is a Rhodes Scholar and a World Economic Forum (WEF) Young Global Leader. Dr. Sabeti received her BS at MIT, her MPhil at Oxford University, and her MD summa cum laude from Harvard Medical School.
Professor, Systems Biology and Organismic and Evolutionary Biology, Harvard University; Professor, Immunology and Infectious Disease, Harvard Chan School of Public Health; Howard Hughes Medical Institute and the Broad Institute of Harvard and MIT