Our Funded Studies

Bay Area Lyme Foundation supports researchers who are working to advance the understanding of Lyme Disease. Thanks to our science committee and scientific advisory board, we have been able to find and fund cutting-edge tick-borne disease research in diagnostics, therapeutics, and ecology. Below is a publication list representing the results of some of the research studies we have supported. We believe that solutions will be developed through new technologies and multidisciplinary approaches. To date, we have funded over 100 innovative projects from 37 institutions across the country.

Therapeutic and Diagnostic Studies Funded by Bay Area Lyme Foundation

 

External Validation of Raman Spectroscopy for Lyme Disease Diagnostics (2025)

 

Evidence for the Presence of Borrelia burgdorferi Biofilm in Infected Mouse Heart Tissues (2024)

 

Fibroblast growth factor receptor inhibitors mitigate the neuropathogenicity of Borrelia burgdorferi or its remnants ex vivo (2024)

 

Highly heterogenous humoral immune response in Lyme disease patients revealed by broad machine learning-assisted antibody binding profiling with random peptide arrays (2024)

 

Cellular and transcriptome signatures unveiled by single-cell RNA-Seq following ex vivo infection of murine splenocytes with Borrelia burgdorferi (2023)

 

Superior efficacy of combination antibiotic therapy versus monotherapy in a mouse model of Lyme disease (2023)

 

Targeting Borrelia burgdorferi HtpG with a berserker molecule, a strategy for anti-microbial development (2023)

 

Metabolic modeling predicts unique drug targets in Borrelia burgdorferi (2023)

 

 

Whole genome sequencing of human Borrelia burgdorferi isolates reveals linked blocks of accessory genome elements located on plasmids and associated with human dissemination (2023)

 

Lyme disease and the pursuit of a clinical cure (2023)

 

 

The FGF/FGFR system in the microglial neuroinflammation with Borrelia burgdorferi: likely intersectionality with other neurological conditions  (2023)

 

Whole genome sequencing of Borrelia burgdorferi isolates reveals linked clusters of plasmid-borne accessory genome elements associated with virulence (2023)

 

More Bay Area Lyme funded studies in our Funded Studies Archive.

 

Lyme Disease Biobank Publications

 

	Frontiers in Medicine (2025 July 10) – Lyme Disease Biobank: 10 years of 3 month follow-up visits from 2014 to 2023
	Heliyon (2024 May 30) – Late-stage borreliosis and substance abuse
	Cureus (2022 Oct 25) – The spectrum of erythema migrans in early Lyme disease: Can we improve its recognition?
	Frontiers in Medicine (2021 Aug 18) – Recent progress in Lyme disease and remaining challenges
	Journal of Clinical Microbiology (2020 May 26) – The Lyme Disease Biobank: Characterization of 550 patient and control samples from the East Coast and Upper Midwest of the United States

 

Published Studies Using Lyme Disease Biobank Samples and Data

 

	Journal of Clinical Microbiology (2025 Sep 10) – A novel single-tier serologic test to diagnose all stages of Lyme disease
	Journal of Clinical Microbiology (2025 Aug 13) – Class and isotype of VlsE-specific antibody differentiates Lyme disease stage
	Frontiers in Immunology (2025 May 15) – Serologic biomarker discovery for differentiating Lyme disease from diseases with similar clinical symptoms using broad profiling of antibody binding
	Journal of Biophotonics (2025 May) – External validation of Raman spectroscopy for Lyme disease diagnostics
	MBio (2024 Oct 16) – Identification of reactive Borrelia burgdorferi peptides associated with Lyme disease
	International Journal of Infectious Disease (2024 Oct) – A set of diagnostic tests for detection of active Babesia duncani infection
	Nature Communications (2024 Aug 20) – Rapid single-tier serodiagnosis of Lyme disease
	eBioMedicine (2024 Jan 23) – Host glycosylation of immunoglobulins impairs the immune response to acute Lyme disease
	Frontiers in Immunology (2024 Jan 22) – Highly heterogenous humoral immune response in Lyme disease patients revealed by broad machine learning-assisted antibody binding profiling with random peptide arrays
	International Journal of General Medicine (2023 Jun 17) – Does biological sex matter in Lyme disease? The need for sex-disaggregated data in persistent illness
	Frontiers in Cellular and Infection Microbiology (2022 Oct 27) – Testing Raman spectroscopy as a diagnostic approach for Lyme disease patients
	Frontiers in Immunology (2022 Aug 5) – Acute Lyme disease IgG N-linked glycans contrast the canonical inflammatory signature
	Frontiers in Microbiology (2022 Mar 7) – Capture sequencing enables sensitive detection of tick-borne agents in human blood
	Journal of Clinical Microbiology (2021 Jan 21) – Serum epitope repertoire analysis enables early detection of Lyme disease with improved sensitivity in an expandable multiplex format
	Scientific Reports Nature Research (2020 Dec 10) – Rapid and sensitive detection of SARS-CoV-2 antibodies by biolayer interferometry
	Computers in Biology and Medicine (2020 Oct) – AI-based detection of erythema migrans and disambiguation against other skin lesions
	Plos One (2020 Feb 10) – A fluorescent plasmonic biochip assay for multiplex screening of diagnostic serum antibody targets in human Lyme disease
	ACS Nano (2020 Jan 28) – Point-of-care serodiagnostic test for early-stage Lyme disease using a multiplexed paper-based immunoassay and machine learning
	Journal of Clinical Microbiology (2019 Nov 22) – A multiplexed serologic test for diagnosis of Lyme disease for point-of-care use