Bay Area Lyme Foundation supports researchers who are working to advance the understanding of Lyme Disease. Thanks to our science committee and scientific advisory board, we have been able to find and fund cutting edge tick-borne disease research in diagnostics, therapeutics and ecology. Below is a publication list representing the results of some of the research studies we have supported. We believe that solutions will be developed through new technologies and multidisciplinary approaches. To date, we have funded over 100 innovative projects from 37 institutions across the country.

Therapeutic and Diagnostic Studies Funded by Bay Area Lyme Foundation

 

Fibroblast growth factor receptor inhibitors mitigate the neuropathogenicity of Borrelia burgdorferi or its remnants ex vivo (2024)

 

Highly heterogenous humoral immune response in Lyme disease patients revealed by broad machine learning-assisted antibody binding profiling with random peptide arrays (2024)

 

Cellular and transcriptome signatures unveiled by single-cell RNA-Seq following ex vivo infection of murine splenocytes with Borrelia burgdorferi (2023)

 

Superior efficacy of combination antibiotic therapy versus monotherapy in a mouse model of Lyme disease (2023)

 

Cell Chemical Biology logo

Targeting Borrelia burgdorferi HtpG with a berserker molecule, a strategy for anti-microbial development (2023)

 

Metabolic modeling predicts unique drug targets in Borrelia burgdorferi (2023)

 

 

PLOS Pathogens logoWhole genome sequencing of human Borrelia burgdorferi isolates reveals linked blocks of accessory genome elements located on plasmids and associated with human dissemination (2023)

 

Lyme disease and the pursuit of a clinical cure (2023)

 

 

BMC - Part of Springer NatureThe FGF/FGFR system in the microglial neuroinflammation with Borrelia burgdorferi: likely intersectionality with other neurological conditions  (2023)

 

Whole genome sequencing of Borrelia burgdorferi isolates reveals linked clusters of plasmid-borne accessory genome elements associated with virulence (2023)

 

Testing Raman spectroscopy as a diagnostic approach for Lyme disease patients  (2022)

 

Increased macrophage phagocytic activity with TLR9 agonist conjugation of an anti- Borrelia burgdorferi monoclonal antibody (2022)

 

Cas9-mediated endogenous plasmid loss in Borrelia burgdorferi (2022)

 

Borrelia burgdorferi Migration Assays for Evaluation of Chemoattractants in Tick Saliva (2022)

 

Borreliella burgdorferi Antimicrobial-Tolerant Persistence in Lyme Disease and Posttreatment Lyme Disease Syndromes (2022)

 

Novel Association of Lyme Disease, Age, and Atopic Dermatitis (2022)

 

International Fournal of Infectious Diseases

Risk of post-treatment Lyme disease in patients with ideally-treated early Lyme disease: A prospective cohort study (2022)

 

The unusual cell wall of the Lyme disease spirochaete Borrelia burgdorferi is shaped by a tick sugarThe unusual cell wall of the Lyme disease spirochaete Borrelia burgdorferi is shaped by a tick sugar (2021)

 

Recent Progress in Lyme Disease and Remaining Challenges (2021)

 

Botanical Medicines Cryptolepis sanguinolenta, Artemisia annua, Scutellaria baicalensis, Polygonum cuspidatum, and Alchornea cordifolia Demonstrate Inhibitory Activity Against Babesia duncani (2021)

 

Antibiotic Susceptibility of Bartonella Grown in Different Culture Conditions  (2021)

 

STAS Domain Only Proteins in Bacterial Gene Regulation (2021)

 

The presenting characteristics of erythema migrans vary by age, sex, duration, and body location (2021)

 

Exploring a possibility of using Raman spectroscopy for detection of Lyme disease (2021)

 

Cohort of Patients Diagnosed with Early Lyme Disease (2020)

 

 

Antibiotic Treatment Response in Chronic Lyme Disease: Why Do Some Patients Improve While Others Do Not? (2020)

 

Evaluation of Natural and Botanical Medicines for Activity Against Growing and Non-growing Forms of B. burgdorferi (2020)

 

Azlocillin can be the potential drug candidate against drug-tolerant Borrelia burgdorferi sensu stricto JLB31 (2020)

 

Detection of Borrelia burgdorferi Cell-free DNA in Human Plasma Samples for Improved Diagnosis of Early Lyme Borreliosis (2020)

 

A fluorescent plasmonic biochip assay for multiplex screening of diagnostic serum antibody targets in human Lyme disease (2020)

 

Evaluation of Natural and Botanical Medicines for Activity Against Growing and Non-growing Forms of B. burgdorferi (2020)

 

ACS Publications Measurement of organ-specific and acute-phase blood-protein levels in early Lyme disease (2020)

 

The generality of post-antimicrobial treatment persistence of replicatively-attenuated Borrelia burgdorferi in a mouse model (2019)

 

Molecular testing of serial blood specimens from patients with early Lyme disease during treatment reveals changing co-infection with mixtures of Borrelia burgdorferi genotypes (2019)

 

Precision medicine: retrospective chart review and data analysis of 200 patients on dapsone combination therapy for chronic Lyme disease/post-treatment Lyme disease syndrome: part 1 (2019)

 

Characterization of Brain Dysfunction Induced by Bacterial Lipopeptides That Alter Neuronal Activity and Network in Rodent Brains (2018)

 

Robust B Cell Responses Predict Rapid Resolution of Lyme Disease (2018)

 

Late Disseminated Lyme Disease Associated Pathology and Spirochete Persistence Posttreatment in Rhesus Macaques (2017)

 

Variable manifestations, diverse seroreactivity and post-treatment persistence in non-human primates exposed to Borrelia burgdorferi by tick feeding (2017)

 

Accuracy of Clinician Suspicion of Lyme Disease in the Emergency Department (2017)

 

Screening of NCI-DTP library to identify new drug candidates for Borrelia burgdorferi (2016)

 

Identification of new drug candidates against Borrelia burgdorferi  using high-throughput screening (2016)

 

Longitudinal Transcriptome Analysis Reveals a Sustained Differential Gene Expression Signature in Patients Treated for Acute Lyme Disease (2016)

 

Borreliacidal activity of Borrelia metal transporter A (BmtA) binding small molecules by manganese transport inhibition (2015)

 

Lyme Disease Biobank Published Studies

Late-stage borreliosis and substance abuse (2024)

 

 

Testing Raman spectroscopy as a diagnostic approach for Lyme disease patients (2022)

 

Recent Progress in Lyme Disease and Remaining Challenges (2021)

 

The Lyme Disease Biobank – Characterization of 550 Patient and Control Samples from the East Coast and Upper Midwest of the United States (2020)

 

 

Published Studies Using Lyme Disease Biobank Samples

Fronteirs

Acute lyme disease IgG N-linked glycans contrast the canonical inflammatory signature (2022)

 

Capture Sequencing Enables Sensitive Detection of Tick-Borne Agents in Human Blood (2022)

 

Adaptive BiotechnologiesImmunosequencing of the T-cell receptor repertoire reveals signatures specific for diagnosis and characterization of early Lyme disease (2021)

 

A fluorescent plasmonic biochip assay for multiplex screening of diagnostic serum antibody targets in human Lyme disease (2020)

 

AI-based detection of erythema migrans and disambiguation against other skin lesions (2020)

 

Point-of-care serodiagnostic test for early-stage Lyme disease using a multiplexed paper-based immunoassay and machine learning (2020)

 

A Multiplexed Serologic Test for Diagnosis of Lyme Disease for Point-of-Care Use (2019)

 

 

Ecology Studies Funded by Bay Area Lyme Foundation

 

Surveillance of Rocky Mountain wood ticks (Dermacentor andersoni) and American dog ticks (Dermacentor variabilis) in Colorado (2022)

 

Examining Prevalence and Diversity of Tick-Borne Pathogens in Questing Ixodes pacificus Ticks in California  (2021)

 

Predicting the current and future distribution of the western black-legged tick, Ixodes pacificus, across the Western US using citizen science collections (2021)

Ecological Fallacy and Aggregated Data: A Case Study of Fried Chicken Restaurants, Obesity and Lyme Disease (2020)

 

Citizen Science Provides an Efficient Method for Broad-Scale Tick-Borne Pathogen Surveillance of Ixodes pacificus and Ixodes scapularis across the United States (2019)

 

The genome of Peromyscus leucopus, natural host for Lyme disease and other emerging infections (2019)

 

Ticks and Tick-borne Diseases – Time of year and outdoor recreation affect human exposure to ticks in California (2019)

 

Drivers and patterns of microbial community assembly in a Lyme disease vector (2019)

 

Citizen science informs human-ticks exposure in the Northeastern United States (2019)

 

Borrelia miyamotoi Infections in Small Mammals, California, USA (2018)

 

Using citizen science to describe the prevalence and distribution of tick bite and exposure to tick-borne diseases in the United States (2018)

 

Lyme disease ecology in a changing world: consensus, uncertainty and critical gaps for improving control (2017)

 

Epidemiology and Genetic Diversity of Anaplasma phagocytophilum in the San Francisco Bay Area, California (2016)

 

Survey of Ixodes pacificus Ticks in California Reveals a Diversity of Microorganisms and a Novel and Widespread Anaplasmataceae Species (2015)

 

Disease Risk & Landscape Attributes of Tick-Borne Borrelia Pathogens in the San Francisco Bay Area, California (2015)

 

Ticks and Tick-borne Diseases – Seasonal activity patterns of the western black-legged tick, Ixodes pacificus, in relation to onset of human Lyme disease in northwestern California (2014)

 

Tick-borne Pathogens in Northwestern California, USA (2014)