Dana Parish, Bay Area Lyme Advisory Board Member (Co-author of "Chronic" and SonyATV singer/ songwriter)
Bay Area Lyme Foundation Advisory Board Member, “Chronic” co-author and SonyATV singer/songwriter, Dana Parish, shares her perspective on chronic diseases, autoimmunity, COVID-19, and speaking out in the face of adversity. “Chronic: The Hidden Cause of the Autoimmune Pandemic and How to Get Healthy Again” is available for purchase on Amazon here.
Jacob Lemieux, MD, PhD (Harvard/MIT Broad Institute)
Bay Area Lyme’s 2020 Emerging Leader Award Winner, Jacob Lemieux, MD, PhD, of the Harvard/MIT Broad Institute, discusses Borrelia and malaria, next-generation sequencing, COVID-19, and Lyme diagnostic challenges.
Artem Rogovsky, DVM, PhD (Texas A & M University)
Bay Area Lyme’s 2020 Emerging Leader Award Winner, Artem Rogovsky, DVM, PhD, of the Department of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, discusses radioactive ticks, Lyme diagnostics, and how a kid’s birthday party can lead to novel research.
Liz Horn, PhD, MBI (Lyme Disease Biobank)
Principal Investigator for the Bay Area Lyme Disease Biobank, Liz Horn, PhD, MBI, discusses the Biobank which has enrolled over 900 participants, supporting over 50 research projects so far. They support research projects across the nation by providing precious serum, whole blood, urine and tissue samples to researchers.
– Wendy Adams, Research Grant Director, Bay Area Lyme Foundation
This pandemic has brought many different modalities in diagnostics, drug development and vaccines to the popular press. In the Tick-borne Disease (TBD) community, we have seen the issues that arise when the timely diagnosis and treatment of infectious disease are hampered by insensitive diagnostics and ineffective treatments.
It bears repeating however, that drugs that fight the infection in question (antibiotics, antiparasitics, or antivirals) are a large part of any eventual solution to an outbreak, especially in advance of a vaccine (see HIV). Antimicrobial therapeutics help keep the pathogen from replicating uncontrolled, allowing the complicated immune system processes to catch up to it, control it and then eradicate it.
One specific treatment modality is being widely discussed: monoclonal antibodies (mAbs). These are the drugs upon which the whole biotech industry and companies like Genentech, Biogen and Amgen were literally built. Six out of the top 10 drugs by sales are mAbs, mostly for oncology and autoimmune disease indications. However, mAbs have not been commonly used for infectious disease (with one major exception we’ll talk about later).
What are monoclonal antibodies? How do they work?
Antibodies are proteins made by the mammalian immune system. They are a workhorse of the acquired immune response and fight specific antigens, which can be anything from an invading pathogen to an aberrant cell or cytokine that needs destruction. Monoclonal antibodies as a drug class are also very specific and only bind to one antigen. They can bind to a single receptor on the outside of a cell, so that cell can’t receive or send out a message. Or the cell can be tagged so the immune system recognizes the cell as foreign and can destroy it. Binding only one target is important to reduce side effects caused by binding to multiple targets.