Lyme Disease Biobank was initiated with a Fund-A-Need campaign at Bay Area Lyme Foundation’s annual LymeAid® benefit (May, 2014). We have enrolled more than 1,200 participants from eight collection sites on the East Coast, in Upper Midwest, and in California. Each participant’s donation provides samples for ~50 research projects, with aliquots of whole blood (1 and 2 ml), serum (250 μl), and urine (1 ml). Several larger aliquots (5 ml) are also available. Detailed clinical information and testing data are also collected to better characterize samples. Currently, more than 80 research projects are using LDB samples. Click here to read a timeline of this program.

You may read the latest published studies using LDB samples and latest news below.


Biobank Published Results


Cureus Part of Springer Nature Cureus (2022 Oct 25) – The spectrum of erythema migrans in early Lyme disease: Can we improve its recognition?
Frontiers logo Frontiers in Medicine (2021 Aug 18) – Recent progress in Lyme disease and remaining challenges
Journal of Clinical Microbiology (2020 May 26) – The Lyme Disease Biobank: Characterization of 550 patient and control samples from the East Coast and Upper Midwest of the United States


Published Studies Using Lyme Disease Biobank Samples


Frontiers logo Frontiers in Cellular and Infection Microbiology (2022 Oct 27) – Testing Raman spectroscopy as a diagnostic approach for Lyme disease patients
Frontiers logo Frontiers in Immunology (2022 Aug 5) – Acute lyme disease IgG N-linked glycans contrast the canonical inflammatory signature
Frontiers logo Frontiers in Microbiology (2022 Mar 7) – Capture sequencing enables sensitive detection of tick-borne agents in human blood
Journal of Clinical Microbiology (2021 Jan 21) – Serum epitope repertoire analysis enables early detection of Lyme disease with improved ssensitivity in an expandable multiplex format


Scientific Reports Nature Research logo Scientific Reports Nature Research (2020 Dec 10) – Rapid and sensitive detection of SARS-CoV-2 antibodies by biolayer interferometry


Plos One (2020 Feb 10) – A fluorescent plasmonic biochip assay for multiplex screening of diagnostic serum antibody targets in human Lyme disease

ACS logo


ACS Nano (2020 Jan 28) – Point-of-care serodiagnostic test for early-stage Lyme disease using a multiplexed paper-based immunoassay and machine learning



Journal of Clinical Microbiology (2019 Nov 22) – A multiplexed serologic test for diagnosis of Lyme disease for point-of-care use


LDB in the News


NDRI Newsletter (Page 14) – NDRI national survey finds Americans strongly support organ and tissue donation for research

Gordon Medical Lyme Disease Biobank Recruiting in Northern and Southern California 

The East Hampton StarEast Hampton Samples Are a Crucial Contributor to Lyme Test

Outbreak News TodayLyme Disease Biobank Expands Into San Diego

Massachusetts News WireBay Area Lyme Foundation announces Lyme Disease Biobank Expands Into San Diego for 2020

San Diego Union TribuneColumn: Ticking bomb: Lyme disease is not an East Coast phenomenon

Send 2 Press NewswireLyme Disease Biobank Expands Into San Diego

Outbreak News TodayNew Study Shows Less Than One-Third of Lyme Disease Test Results are Accurate for Patients with Lyme Rash


lymedisease.orgDonate samples to Lyme Disease Biobank to aid research

Gordon MedicalLyme Disease Biobank – Recruiting in Northern and Southern California

WFMZ-TV 69Bay Area Lyme Foundation Highlights 2019 Progress toward Diagnosing, Treating and Preventing Lyme Disease

PR NewswireJournal of Clinical Microbiology Publishes First Study Using Samples from the Lyme Disease Biobank

Business InsiderFirst West Coast CME Program on Tick-borne Disease Provides New Data, Insights from Researchers


Outbreak News TodayLyme Disease Biobank expands to increase understanding of disease in heart, brain, joints and other tissues

BiospaceBay Area Lyme Foundation Endorses First Recommendations of New HHS Working Group Focused on Tick Borne Diseases

Markets Insider – Bay Area Lyme Foundation and Project Lyme Join Forces to Fight Lyme Disease at the 2018 Lyme Gala

Advancement of Science (AAAS)Lyme Disease Biobank expands to increase understanding of Lyme in heart, brain, joints

HealthlineHere’s Why Lyme Disease Keeps Spreading in the U.S.

Look to the StarsJay Leno Emcees Bay Area Lyme Foundation’s LymeAid 2018 

PR NewswireBay Area Lyme Foundation’s LymeAid® 2018 Raises $1.1 Million for Lyme Disease Research


We would like to recognize and thank the Steven & Alexandra Cohen Foundation, the LaureL STEM Fund, an anonymous donor, and the 2014 & 2018 LymeAid Fund-a-Need supporters who have contributed significantly to our Lyme Disease Biobank.

We are grateful to the participants who volunteered and donated samples.