Bay Area Lyme Foundation supports researchers who are working to advance the understanding of Lyme Disease. Thanks to our science committee and scientific advisory board, we have been able to find and fund cutting edge tick-borne disease research in diagnostics, therapeutics and ecology. Below is a publication list representing the results of some of the research studies we have supported. We believe that solutions will be developed through new technologies and multidisciplinary approaches. To date, we have funded over 100 innovative projects from 37 institutions across the country.

Therapeutic and Diagnostic Studies Funded by Bay Area Lyme Foundation


The unusual cell wall of the Lyme disease spirochaete Borrelia burgdorferi is shaped by a tick sugarThe unusual cell wall of the Lyme disease spirochaete Borrelia burgdorferi is shaped by a tick sugar


Recent Progress in Lyme Disease and Remaining Challenges


Antibiotic Susceptibility of Bartonella Grown in Different Culture Conditions


STAS Domain Only Proteins in Bacterial Gene Regulation


The presenting characteristics of erythema migrans vary by age, sex, duration, and body location


Exploring a possibility of using Raman spectroscopy for detection of Lyme disease


Journal of Clinical Microbiology (2020) – Molecular Microbiological and Immune Characterization of a Cohort of Patients Diagnosed with Early Lyme Disease


Antibiotic Treatment Response in Chronic Lyme Disease: Why Do Some Patients Improve While Others Do Not? (2020)


Evaluation of Natural and Botanical Medicines for Activity Against Growing and Non-growing Forms of B. burgdorferi (2020)


Azlocillin can be the potential drug candidate against drug-tolerant Borrelia burgdorferi sensu stricto JLB31 (2020)


Detection of Borrelia burgdorferi Cell-free DNA in Human Plasma Samples for Improved Diagnosis of Early Lyme Borreliosis (2020)


A fluorescent plasmonic biochip assay for multiplex screening of diagnostic serum antibody targets in human Lyme disease (2020)


Measurement of organ-specific and acute-phase blood-protein levels in early Lyme disease (2020)


The generality of post-antimicrobial treatment persistence of replicatively-attenuated Borrelia burgdorferi in a mouse model (2019)


Molecular testing of serial blood specimens from patients with early Lyme disease during treatment reveals changing co-infection with mixtures of Borrelia burgdorferi genotypes (2019)


Precision medicine: retrospective chart review and data analysis of 200 patients on dapsone combination therapy for chronic Lyme disease/post-treatment Lyme disease syndrome: part 1 (2019)


Characterization of Brain Dysfunction Induced by Bacterial Lipopeptides That Alter Neuronal Activity and Network in Rodent Brains (2018)


Robust B Cell Responses Predict Rapid Resolution of Lyme Disease (2018)


Late Disseminated Lyme Disease Associated Pathology and Spirochete Persistence Posttreatment in Rhesus Macaques (2017)


Variable manifestations, diverse seroreactivity and post-treatment persistence in non-human primates exposed to Borrelia burgdorferi by tick feeding (2017)


Accuracy of Clinician Suspicion of Lyme Disease in the Emergency Department (2017)


Screening of NCI-DTP library to identify new drug candidates for Borrelia burgdorferi (2016)


Identification of new drug candidates against Borrelia burgdorferi  using high-throughput screening (2016)


Longitudinal Transcriptome Analysis Reveals a Sustained Differential Gene Expression Signature in Patients Treated for Acute Lyme Disease (2016)


Borreliacidal activity of Borrelia metal transporter A (BmtA) binding small molecules by manganese transport inhibition (2015)


Ecology Studies Funded by Bay Area Lyme Foundation


Examining Prevalence and Diversity of Tick-Borne Pathogens in Questing Ixodes pacificus Ticks in California


PLOS One (2021): Predicting the current and future distribution of the western black-legged tick, Ixodes pacificus, across the Western US using citizen science collections

Springer Link (2020): Ecological Fallacy and Aggregated Data: A Case Study of Fried Chicken Restaurants, Obesity and Lyme Disease


Science Advances (2019): The genome of Peromyscus leucopus, natural host for Lyme disease and other emerging infections


Elsevier (2019):  Ticks and Tick-borne Diseases – Time of year and outdoor recreation affect human exposure to ticks in California


NCBI – Ecology and Evolution (2019): Drivers and patterns of microbial community assembly in a Lyme disease vector


International Journal of Health Geographics (2019): Citizen science informs human-ticks exposure in the Northeastern United States


Emerging Infectious Disease (2018): Borrelia miyamotoi Infections in Small Mammals, California, USA


PLOS One (2018): Using citizen science to describe the prevalence and distribution of tick bite and exposure to tick-borne diseases in the United States


The Royal Society (2017): Lyme disease ecology in a changing world: consensus, uncertainty and critical gaps for improving control


ASTMH (2016): Epidemiology and Genetic Diversity of Anaplasma phagocytophilum in the San Francisco Bay Area, California


PLOS One (2015): Survey of Ixodes pacificus Ticks in California Reveals a Diversity of Microorganisms and a Novel and Widespread Anaplasmataceae Species


PLOS One (2015): Disease Risk & Landscape Attributes of Tick-Borne Borrelia Pathogens in the San Francisco Bay Area, California


Elsevier (2014): Ticks and Tick-borne Diseases – Seasonal activity patterns of the western black-legged tick, Ixodes pacificus, in relation to onset of human Lyme disease in northwestern California


Emerging Infectious Disease (2014): Tick-borne Pathogens in Northwestern California, USA


Lyme Disease Biobank Published Studies


Recent Progress in Lyme Disease and Remaining Challenges



Journal of Clinical Microbiology (2020)
The Lyme Disease Biobank – Characterization of 550 Patient and Control Samples from the East Coast and Upper Midwest of the United States


Published Studies Using Lyme Disease Biobank Samples


Adaptive BiotechnologiesmedRxiv (2021) – Immunosequencing of the T-cell receptor repertoire reveals signatures specific for diagnosis and characterization of early Lyme disease


PLOS One (2020) – A fluorescent plasmonic biochip assay for multiplex screening of diagnostic serum antibody targets in human Lyme disease

Computers in Biology and Medicine (2020):  AI-based detection of erythema migrans and disambiguation against other skin lesions


Journal of Clinical Microbiology (2019) – A Multiplexed Serologic Test for Diagnosis of Lyme Disease for Point-of-Care Use


ACS Nano (2019) – Point-of-care serodiagnostic test for early-stage Lyme disease using a multiplexed paper-based immunoassay and machine learning