Bay Area Lyme Foundation supports researchers who are working to advance the understanding of Lyme Disease. Thanks to our science committee and scientific advisory board, we have been able to find and fund cutting edge tick-borne disease research in diagnostics, therapeutics and ecology. Below is a publication list representing the results of some of the research studies we have supported. We believe that solutions will be developed through new technologies and multidisciplinary approaches. To date, we have funded over 100 innovative projects from 37 institutions across the country.

Therapeutic and Diagnostic Studies Funded by Bay Area Lyme Foundation

 

Journal of Clinical Microbiology (2020) – Molecular Microbiological and Immune Characterization of a Cohort of Patients Diagnosed with Early Lyme Disease

 

Antibiotic Treatment Response in Chronic Lyme Disease: Why Do Some Patients Improve While Others Do Not? (2020)

 

Evaluation of Natural and Botanical Medicines for Activity Against Growing and Non-growing Forms of B. burgdorferi (2020)

 

Azlocillin can be the potential drug candidate against drug-tolerant Borrelia burgdorferi sensu stricto JLB31 (2020)

 

Detection of Borrelia burgdorferi Cell-free DNA in Human Plasma Samples for Improved Diagnosis of Early Lyme Borreliosis (2020)

 

A fluorescent plasmonic biochip assay for multiplex screening of diagnostic serum antibody targets in human Lyme disease (2020)

 

Measurement of organ-specific and acute-phase blood-protein levels in early Lyme disease (2020)

 

The generality of post-antimicrobial treatment persistence of replicatively-attenuated Borrelia burgdorferi in a mouse model (2019)

 

Molecular testing of serial blood specimens from patients with early Lyme disease during treatment reveals changing co-infection with mixtures of Borrelia burgdorferi genotypes (2019)

 

Precision medicine: retrospective chart review and data analysis of 200 patients on dapsone combination therapy for chronic Lyme disease/post-treatment Lyme disease syndrome: part 1 (2019)

 

Characterization of Brain Dysfunction Induced by Bacterial Lipopeptides That Alter Neuronal Activity and Network in Rodent Brains (2018)

 

Robust B Cell Responses Predict Rapid Resolution of Lyme Disease (2018)

 

Late Disseminated Lyme Disease Associated Pathology and Spirochete Persistence Posttreatment in Rhesus Macaques (2017)

 

Variable manifestations, diverse seroreactivity and post-treatment persistence in non-human primates exposed to Borrelia burgdorferi by tick feeding (2017)

 

Accuracy of Clinician Suspicion of Lyme Disease in the Emergency Department (2017)

 

Screening of NCI-DTP library to identify new drug candidates for Borrelia burgdorferi (2016)

 

Identification of new drug candidates against Borrelia burgdorferi  using high-throughput screening (2016)

 

Longitudinal Transcriptome Analysis Reveals a Sustained Differential Gene Expression Signature in Patients Treated for Acute Lyme Disease (2016)

 

Borreliacidal activity of Borrelia metal transporter A (BmtA) binding small molecules by manganese transport inhibition (2015)

 

Ecology Studies Funded by Bay Area Lyme Foundation

 

Springer Link (2020): Ecological Fallacy and Aggregated Data: A Case Study of Fried Chicken Restaurants, Obesity and Lyme Disease

 

Science Advances (2019): The genome of Peromyscus leucopus, natural host for Lyme disease and other emerging infections

 

Elsevier (2019):  Ticks and Tick-borne Diseases – Time of year and outdoor recreation affect human exposure to ticks in California

 

NCBI – Ecology and Evolution (2019): Drivers and patterns of microbial community assembly in a Lyme disease vector

 

International Journal of Health Geographics (2019): Citizen science informs human-ticks exposure in the Northeastern United States

 

Emerging Infectious Disease (2018): Borrelia miyamotoi Infections in Small Mammals, California, USA

 

PLOS One (2018): Using citizen science to describe the prevalence and distribution of tick bite and exposure to tick-borne diseases in the United States

 

The Royal Society (2017): Lyme disease ecology in a changing world: consensus, uncertainty and critical gaps for improving control

 

ASTMH (2016): Epidemiology and Genetic Diversity of Anaplasma phagocytophilum in the San Francisco Bay Area, California

 

PLOS One (2015): Survey of Ixodes pacificus Ticks in California Reveals a Diversity of Microorganisms and a Novel and Widespread Anaplasmataceae Species

 

PLOS One (2015): Disease Risk & Landscape Attributes of Tick-Borne Borrelia Pathogens in the San Francisco Bay Area, California

 

Elsevier (2014): Ticks and Tick-borne Diseases – Seasonal activity patterns of the western black-legged tick, Ixodes pacificus, in relation to onset of human Lyme disease in northwestern California

 

Emerging Infectious Disease (2014): Tick-borne Pathogens in Northwestern California, USA

 

Lyme Disease Biobank Published Results

 

 

Journal of Clinical Microbiology (2020)
The Lyme Disease Biobank – Characterization of 550 Patient and Control Samples from the East Coast and Upper Midwest of the United States

 

Published Studies Using Lyme Disease Biobank Samples

 

Journal of Clinical Microbiology (2019) – A Multiplexed Serologic Test for Diagnosis of Lyme Disease for Point-of-Care Use

 

ACS Nano (2019) – Point-of-care serodiagnostic test for early-stage Lyme disease using a multiplexed paper-based immunoassay and machine learning

PLOS One (2020) – A fluorescent plasmonic biochip assay for multiplex screening of diagnostic serum antibody targets in human Lyme disease

Computers in Biology and Medicine (2020):  AI-based detection of erythema migrans and disambiguation against other skin lesions